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ctip  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology ctip
    Ctip, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 91 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti+ctip/CtIP+Antibody/pmc12917874-60-55-57
    Average 93 stars, based on 91 article reviews
    ctip - by Bioz Stars, 2026-09
    93/100 stars

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    other:

    Article Title: ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks.
    Article Snippet: Antibodies: anti-CtIP (1:500; Santa Cruz Biotechnology sc-28324), anti-MRE11 (1:1000: Novus Biologicals NB100-142), anti-phospho H2AX (1:5000; Sigma Aldrich 05-636), and anti-NBS1 (1:1000, GeneTex GTX70224).

    Article Title: ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks
    Article Snippet: Antibodies: anti-CtIP (1:500; Santa Cruz Biotechnology sc-28324), anti-MRE11 (1:1000: Novus Biologicals NB100-142), anti-phospho H2AX (1:5000; Sigma Aldrich 05-636), and anti-NBS1 (1:1000, GeneTex GTX70224).

    Article Title: β‐ TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
    Article Snippet: Mouse monoclonal anti‐PARP (1 : 750 #551024, RRID:AB_394008) and anti‐β‐catenin (1 : 10 000, #610153) were from BD Biosciences (San Jose, CA, USA); mouse monoclonal anti‐CtIP (1 : 1000, #sc‐271339, RRID:AB_10608728), anti‐CDK1 (1 : 4000, #sc‐54, RRID:AB_627224), and anti‐actinin (1 : 500, #sc‐17829, RRID:AB_626633) and anti‐RAD51 (1 : 50, #sc‐53428, RRID:AB_630180) were from Santa Cruz Biotechnology (Dallas, TX, USA); mouse monoclonal anti‐β‐actin (1 : 20 000, #A5441, RRID:AB_476744), anti‐α‐tubulin (1 : 20 000, #T9026, RRID:AB_477593), rabbit polyclonal anti‐LC3B (1 : 2000, #L7543, RRID:AB_796155), and rabbit polyclonal anti‐P62/SQSTM1 (1 : 2000, #SAB5701338) were from Sigma‐Aldrich; rabbit polyclonal anti‐cleaved caspase‐3 (Asp175) (1 : 750, #9664, RRID:AB_2070042), anti‐Wee1 (1 : 1000, #4936, RRID:AB_2288509), and anti‐β‐TrCP (1 : 500, #4394, RRID:AB_10545763) were from Cell Signaling (Danvers, MA, USA); mouse monoclonal anti‐hemagglutinin (HA)‐peroxidase (1 : 3000, #12013819001, Roche Cat# 12013819001, RRID:AB_390917) was from Roche; rabbit polyclonal anti‐BRCA1 (1 : 2000, #ab191042, RRID:AB_2650501) was from Abcam (Cambridge, UK); rabbit policlonal anti‐Mcl‐1 (1 : 1000, #ADI‐AAP‐240, RRID:AB_2039361) was from Enzo (Farmingdale, NY, USA); mouse monoclonal anti‐γH2AX Ser139 (1 : 5000, #05‐636, RRID:AB_309864) and anti‐PLK1 (1 : 5000, #05‐844, RRID:AB_310836) were from Merck‐Millipore (Burlington, MA, USA).

    Article Title: BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08.
    Article Snippet: Primary antibodies included antiBRCA1 (1:1000, MS110, Invitrogen), anti-CtIP (1:100, sc-271339, Santa Cruz), anti-FOXA1 (1:1000, 53528, Cell Signaling Technology), anti-γ-H2AX (1:1000, ab20669, Abcam), anti-β-Actin (1:10000, ab8226, Abcam), anti-GAPDH (1:10000, ab8245, Abcam) and anti-H3 (1:10000, ab1791, Abcam).

    Western Blot:

    Article Title: Increasing DNA damage sensitivity through corylin-mediated inhibition of homologous recombination.
    Article Snippet: Background: DNA repair allows the survival of cancer cells.. Therefore, the development of DNA repair inhibitors is a critical need for sensitizing cancers to chemoradiation.. Sae2CtIP has specific functions in initiating DNA end resection, as well as coordinating cell cycle checkpoints, and it also greatly interacts with the DDR at different

    Article Title: RAD51 is chromatin enriched and targetable in BRCA1-deficient cells.
    Article Snippet: .. Primary antibodies for western blot analysis included: anti-MDC1 (Abcam11169, Abcam241048), anti-53BP1 (Novus Biologicals NB100-304), anti-HLTF (Abcam17984), anti-CTIP (Santa Cruz Biotechnology sc-271339), anti-RAD51 (Abcam63801), anti-phospho-H2AX (Millipore 05-636), anti-RPA70 (Cell Signaling #2267S), anti-PALB2 (Abcam 202970), antiBRCA2 (Upstate 05666), anti-Vinculin (Abcam AB91459), anti-β-actin (Sigma-Aldrich A1978), anti-H2B (Cell Signaling Technology 8135). .. Secondary antibodies include: horseradish peroxidase (HRP)-linked ECL anti-rabbit IgG (from donkey, GE Healthcare NA934) and HRP-linked F(ab’)2 fragment ECL anti-mouse IgG (from sheep, Thermo Fisher Scientific NA9310).

    Article Title: Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
    Article Snippet: .. Antibodies for western blot analysis included anti-β-actin (Sigma, A5441), anti-CtIP (Santa Cruz, SC-271339), anti-53BP1 (Novus Biological, NB100–304), anti-MYC (Millipore Sigma, 05–724), anti-γH2AX (EMD Millipore, JBW301) and anti-MDC1 (Abcam, 11169). .. Membranes were washed, incubated with corresponding horseradish peroxidase-linked secondary antibodies (Amersham, GE Healthcare) for 1 h at room temperature and detected by chemiluminescence imaging system (Bio-Rad).



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    MMEJ induced by Cas9 and Cas9n exhibits distinct genetic dependence. ( A-C ) MMEJ was assayed in U2OS (EGFP-MMEJ) cells expressing shRNAs for Polθ ( A ), LIG3 ( A ), RPA2 ( B <t>),</t> <t>MRE11</t> ( C ) or <t>CtIP</t> ( C ) after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( D ) MMEJ was assayed in WT or POLQ -KO mES (EGFP-MMEJ) cells four days after transfection of plasmids encoding g2/Cas9 WT or g2/Cas9 D10A . ( E ) mES (EGFP-MMEJ) cells with POLQ WT allele or knock-in (KI) alleles containing mutations of K120G or D2494P/E2495R were assayed for MMEJ after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( F ) In vitro biochemical assay showing Polθ-HelD activity in unwinding dsDNA to facilitate strand exchange with ssDNA carrying 15 bp homology. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrate and incubated with Polθ-HelD, ATP and/or RPA, and the reaction products were resolved on a non-denaturing gel. ( G ) In vitro biochemical assay showing strand displacement DNA synthesis by Polθ-HelD and Polθ-PolD. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrates and incubated with Polθ-HelD, ATP and/or RPA, followed by DNA extension with Polθ-PolD with 0.1 mM dNTPs, and the reaction products were resolved on a denaturing gel.
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    MMEJ induced by Cas9 and Cas9n exhibits distinct genetic dependence. ( A-C ) MMEJ was assayed in U2OS (EGFP-MMEJ) cells expressing shRNAs for Polθ ( A ), LIG3 ( A ), RPA2 ( B <t>),</t> <t>MRE11</t> ( C ) or <t>CtIP</t> ( C ) after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( D ) MMEJ was assayed in WT or POLQ -KO mES (EGFP-MMEJ) cells four days after transfection of plasmids encoding g2/Cas9 WT or g2/Cas9 D10A . ( E ) mES (EGFP-MMEJ) cells with POLQ WT allele or knock-in (KI) alleles containing mutations of K120G or D2494P/E2495R were assayed for MMEJ after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( F ) In vitro biochemical assay showing Polθ-HelD activity in unwinding dsDNA to facilitate strand exchange with ssDNA carrying 15 bp homology. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrate and incubated with Polθ-HelD, ATP and/or RPA, and the reaction products were resolved on a non-denaturing gel. ( G ) In vitro biochemical assay showing strand displacement DNA synthesis by Polθ-HelD and Polθ-PolD. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrates and incubated with Polθ-HelD, ATP and/or RPA, followed by DNA extension with Polθ-PolD with 0.1 mM dNTPs, and the reaction products were resolved on a denaturing gel.
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    MMEJ induced by Cas9 and Cas9n exhibits distinct genetic dependence. ( A-C ) MMEJ was assayed in U2OS (EGFP-MMEJ) cells expressing shRNAs for Polθ ( A ), LIG3 ( A ), RPA2 ( B ), MRE11 ( C ) or CtIP ( C ) after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( D ) MMEJ was assayed in WT or POLQ -KO mES (EGFP-MMEJ) cells four days after transfection of plasmids encoding g2/Cas9 WT or g2/Cas9 D10A . ( E ) mES (EGFP-MMEJ) cells with POLQ WT allele or knock-in (KI) alleles containing mutations of K120G or D2494P/E2495R were assayed for MMEJ after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( F ) In vitro biochemical assay showing Polθ-HelD activity in unwinding dsDNA to facilitate strand exchange with ssDNA carrying 15 bp homology. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrate and incubated with Polθ-HelD, ATP and/or RPA, and the reaction products were resolved on a non-denaturing gel. ( G ) In vitro biochemical assay showing strand displacement DNA synthesis by Polθ-HelD and Polθ-PolD. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrates and incubated with Polθ-HelD, ATP and/or RPA, followed by DNA extension with Polθ-PolD with 0.1 mM dNTPs, and the reaction products were resolved on a denaturing gel.

    Journal: bioRxiv

    Article Title: Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks

    doi: 10.64898/2026.01.15.699632

    Figure Lengend Snippet: MMEJ induced by Cas9 and Cas9n exhibits distinct genetic dependence. ( A-C ) MMEJ was assayed in U2OS (EGFP-MMEJ) cells expressing shRNAs for Polθ ( A ), LIG3 ( A ), RPA2 ( B ), MRE11 ( C ) or CtIP ( C ) after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( D ) MMEJ was assayed in WT or POLQ -KO mES (EGFP-MMEJ) cells four days after transfection of plasmids encoding g2/Cas9 WT or g2/Cas9 D10A . ( E ) mES (EGFP-MMEJ) cells with POLQ WT allele or knock-in (KI) alleles containing mutations of K120G or D2494P/E2495R were assayed for MMEJ after g2/Cas9 WT or g2/Cas9 D10A cleavage. ( F ) In vitro biochemical assay showing Polθ-HelD activity in unwinding dsDNA to facilitate strand exchange with ssDNA carrying 15 bp homology. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrate and incubated with Polθ-HelD, ATP and/or RPA, and the reaction products were resolved on a non-denaturing gel. ( G ) In vitro biochemical assay showing strand displacement DNA synthesis by Polθ-HelD and Polθ-PolD. 32 P-5’-labeled ssDNA was mixed with the indicated dsDNA substrates and incubated with Polθ-HelD, ATP and/or RPA, followed by DNA extension with Polθ-PolD with 0.1 mM dNTPs, and the reaction products were resolved on a denaturing gel.

    Article Snippet: Antibodies used in immunoblotting are: MRE11 (Cell Signaling Technology, 4895), CtIP (Proteintech, 12624-1-AP), RPA1 (Sigma-Aldrich, NA13), RPA2 (Bethyl, A300-244A), PCNA (Cell Signaling Technology, 13110), MCM2 (Proteintech, 10513-1-AP), DNA2 (Proteintech, 18727-1-AP), KU70 (Santa Cruz Biotechnology, sc-17789), HA (Santa Cruz Biotechnology, sc-7392), Flag (Sigma-Aldrich, F1804), BLM (Bethyl, A300-110A), EXO1 (Bethyl, A302-640A), ATR (Santa Cruz Biotechnology, sc-515173), BRCA1 (Santa Cruz Biotechnology, sc-6954), RAD51 (Santa Cruz Biotechnology, sc-398587), LIG3 (Proteintech, 26583-1-AP), γH2AX (Upstate, 07-164), Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L) (Jackson ImmunoResearch Labs, 115-035-146), and Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L) (Jackson ImmunoResearch Labs, 111-035-144).

    Techniques: Expressing, Transfection, Knock-In, In Vitro, Activity Assay, Labeling, Incubation, DNA Synthesis

    Fork-MMEJ functions together with BIR to repair seDSBs on broken forks. ( A ) Schematic drawings of the EGFP-MMEJ/mCherry-BIR reporter and the repair products by cMMEJ and BIR after Cas9 WT cleavage. The gRNA2 cleavage site is indicated. ( B ) MMEJ or BIR was scored in U2OS (EGFP-MMEJ/mCherry-BIR) cells by FACS to determine EGFP or mCherry positive cells after cleavage by gRNA2 with Cas9 WT and Cas9 D10A . ( C ) Time course experiments were performed in U2OS (EGFP-MMEJ/mCherry-BIR) cells to analyze MMEJ and BIR after cleavage by gRNA2 with Cas9 WT and Cas9 D10A . ( D - F ) MMEJ and BIR was assayed in U2OS (EGFP-MMEJ/mCherry-BIR) cells expressing shRNAs for CtIP ( D ), MRE11 ( D ), PIF1( E ) or Polθ ( F ) after expressing gRNA2 with Cas9 and Cas9n.

    Journal: bioRxiv

    Article Title: Microhomology-mediated end joining acts directly on replication forks to repair single-ended double strand breaks

    doi: 10.64898/2026.01.15.699632

    Figure Lengend Snippet: Fork-MMEJ functions together with BIR to repair seDSBs on broken forks. ( A ) Schematic drawings of the EGFP-MMEJ/mCherry-BIR reporter and the repair products by cMMEJ and BIR after Cas9 WT cleavage. The gRNA2 cleavage site is indicated. ( B ) MMEJ or BIR was scored in U2OS (EGFP-MMEJ/mCherry-BIR) cells by FACS to determine EGFP or mCherry positive cells after cleavage by gRNA2 with Cas9 WT and Cas9 D10A . ( C ) Time course experiments were performed in U2OS (EGFP-MMEJ/mCherry-BIR) cells to analyze MMEJ and BIR after cleavage by gRNA2 with Cas9 WT and Cas9 D10A . ( D - F ) MMEJ and BIR was assayed in U2OS (EGFP-MMEJ/mCherry-BIR) cells expressing shRNAs for CtIP ( D ), MRE11 ( D ), PIF1( E ) or Polθ ( F ) after expressing gRNA2 with Cas9 and Cas9n.

    Article Snippet: Antibodies used in immunoblotting are: MRE11 (Cell Signaling Technology, 4895), CtIP (Proteintech, 12624-1-AP), RPA1 (Sigma-Aldrich, NA13), RPA2 (Bethyl, A300-244A), PCNA (Cell Signaling Technology, 13110), MCM2 (Proteintech, 10513-1-AP), DNA2 (Proteintech, 18727-1-AP), KU70 (Santa Cruz Biotechnology, sc-17789), HA (Santa Cruz Biotechnology, sc-7392), Flag (Sigma-Aldrich, F1804), BLM (Bethyl, A300-110A), EXO1 (Bethyl, A302-640A), ATR (Santa Cruz Biotechnology, sc-515173), BRCA1 (Santa Cruz Biotechnology, sc-6954), RAD51 (Santa Cruz Biotechnology, sc-398587), LIG3 (Proteintech, 26583-1-AP), γH2AX (Upstate, 07-164), Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L) (Jackson ImmunoResearch Labs, 115-035-146), and Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L) (Jackson ImmunoResearch Labs, 111-035-144).

    Techniques: Expressing